Sinequan is very sedating

Although the various classes of CNS depressants work in different ways, ultimately it is through their ability to increase GABA activity (thereby decreasing brain activity) that they produce a drowsy or calming effect that is beneficial to those suffering from anxiety or sleep disorders.

Barbiturates (a class of drugs with more effective sedative-hypnotic effects) replaced bromides in 1903.

Used primarily to treat insomnia as well as a wide variety of anxiety disorders, tranquilizers are among the most commonly prescribed—and abused—psychiatric medications in the United States.

According to Food and Drug Administration (FDA) estimates, over 60 million people receive prescriptions for tranquilizers every year.

As a group, tranquilizers act mostly on the brain by affecting the neurotransmitter gamma-aminobutyric acid (GABA).

Neurotransmitters are brain chemicals that facilitate communication between brain cells (neurons).

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This term, however, arose from the inaccurate belief that the major positive action of the earliest drugs used to treat this illness was sedating and that these drugs were on a continuum with other, less powerful, antianxiety drugs.

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  1. Although the various classes of CNS depressants work in different ways, ultimately it is through their ability to increase GABA activity (thereby decreasing brain activity) that they produce a drowsy or calming effect that is beneficial to those suffering from anxiety or sleep disorders.